| Reaction Details |
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 | Report a problem with these data |
| Target | HIV WT-C pol protein (wild-type clade C) |
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| Ligand | BDBM577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Drug Susceptibility Assay |
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| EC50 | 3.7±0.0 nM |
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| Citation |  Shen, Y; Altman, MD; Ali, A; Nalam, MN; Cao, H; Rana, TM; Schiffer, CA; Tidor, B Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol8:2433-41 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| HIV WT-C pol protein (wild-type clade C) |
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| Name: | HIV WT-C pol protein (wild-type clade C) |
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| Synonyms: | Gag-Pol polyprotein [489-892,I504V,M525I,R530K,H558K,L578M,I582L,V609I,V623T,E624A,T627E,E628D,K631R,Q690K,D711S,C750S,D765E,T788A,Q795E,R799K,P831S,V833E,D838E,A860P,R865K,E879D,V880I] | POL_HV1N5 | WT-C | gag-pol |
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| Type: | Protein |
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| Mol. Mass.: | 45932.56 |
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| Organism: | Human immunodeficiency virus |
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| Description: | P12497[489-892,I504V,M525I,R530K,H558K,L578M,I582L,V609I,V623T,E624A,T627E,E628D,K631R,Q690K,D711S,C750S,D765E,T788A,Q795E,R799K,P831S,V833E,D838E,A860P,R865K,E879D,V880I] |
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| Residue: | 404 |
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| Sequence: | PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNFPISPIETVPVKLKPGMDGPKI
KQWPLTEEKIKALTAICEDMEREGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELN
KRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKSFRKYTAFTIPSINNETPG
IRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHRAK
IEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQSIELPEKESWTVNDIQKLV
GKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAELELAE
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| BDBM577 |
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| n/a |
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| Name | BDBM577 |
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| Synonyms: | (3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-methylpropyl)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate | 141W94 | APV | Agenerase | Amprenavir | BDBM50215393 | CHEMBL116 | VX-478 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H35N3O6S |
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| Mol. Mass. | 505.627 |
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| SMILES | CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1 |r| |
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| Structure | 
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