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TargetPolymerase acidic protein [1-204,T86I,G186S]
LigandBDBM105185
Substrate/Competitorn/a
IC50 3.00e+5±n/a nM
Citation Bauman, JDPatel, DBaker, SFVijayan, RSXiang, AParhi, AKMartínez-Sobrido, LMartínez-Sobrido, EJDas, KArnold, E Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. ACS Chem Biol8:2501-8 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polymerase acidic protein [1-204,T86I,G186S]
Name:Polymerase acidic protein [1-204,T86I,G186S]
Synonyms:2009 H1N1 Influenza polymerase acidic protein N-terminal endonuclease domain | H1N1 Endonuclease | PA | PA_I80A6
Type:Protein
Mol. Mass.:28455.35
Organism:2009 H1N1 Influenza
Description:P13166[1-204,T86I,G186S]
Residue:241
Sequence:
MAHHHHHHSRAWRHPQFGGHHHHHHALEVLFQGPLGSMEDFVRQCFNPMIVELAEKAMKE
YGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRD
RIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKT
HIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEETVEE
R
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  Blast E-value cutoff:
BDBM105185
n/a
NameBDBM105185
Synonyms:7-aminothieno[2,3-b]pyrazine-6-carboxylic acid (MB41-1)
TypeSmall organic molecule
Emp. Form.C7H5N3O2S
Mol. Mass.195.199
SMILESNc1c(sc2nccnc12)C(O)=O
Structure
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