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TargetPolymerase acidic protein [1-204,T86I,G186S]
LigandBDBM50027331
Substrate/Competitorn/a
IC50 1.00e+5±n/a nM
Citation Bauman, JDPatel, DBaker, SFVijayan, RSXiang, AParhi, AKMartínez-Sobrido, LMartínez-Sobrido, EJDas, KArnold, E Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. ACS Chem Biol8:2501-8 (2013) [PubMed]  Article
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Polymerase acidic protein [1-204,T86I,G186S]
Name:Polymerase acidic protein [1-204,T86I,G186S]
Synonyms:2009 H1N1 Influenza polymerase acidic protein N-terminal endonuclease domain | H1N1 Endonuclease | PA | PA_I80A6
Type:Protein
Mol. Mass.:28455.35
Organism:2009 H1N1 Influenza
Description:P13166[1-204,T86I,G186S]
Residue:241
Sequence:
MAHHHHHHSRAWRHPQFGGHHHHHHALEVLFQGPLGSMEDFVRQCFNPMIVELAEKAMKE
YGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRD
RIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKT
HIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEETVEE
R
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  Blast E-value cutoff:
BDBM50027331
n/a
NameBDBM50027331
Synonyms:1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol | 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide (JW8-5) | CHEMBL19068 | norlaudanosoline
TypeSmall organic molecule
Emp. Form.C16H17NO4
Mol. Mass.287.3105
SMILESOc1ccc(CC2NCCc3cc(O)c(O)cc23)cc1O
Structure
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