| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein [1-204,T86I,G186S] |
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| Ligand | BDBM50291683 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fragment Screening |
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| IC50 | 2e+3±n/a nM |
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| Citation |  Bauman, JD; Patel, D; Baker, SF; Vijayan, RS; Xiang, A; Parhi, AK; Martínez-Sobrido, L; Martínez-Sobrido, EJ; Das, K; Arnold, E Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. ACS Chem Biol8:2501-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein [1-204,T86I,G186S] |
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| Name: | Polymerase acidic protein [1-204,T86I,G186S] |
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| Synonyms: | 2009 H1N1 Influenza polymerase acidic protein N-terminal endonuclease domain | H1N1 Endonuclease | PA | PA_I80A6 |
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| Type: | Protein |
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| Mol. Mass.: | 28455.35 |
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| Organism: | 2009 H1N1 Influenza |
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| Description: | P13166[1-204,T86I,G186S] |
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| Residue: | 241 |
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| Sequence: | MAHHHHHHSRAWRHPQFGGHHHHHHALEVLFQGPLGSMEDFVRQCFNPMIVELAEKAMKE
YGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRD
RIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKT
HIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEETVEE
R
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| BDBM50291683 |
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| n/a |
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| Name | BDBM50291683 |
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| Synonyms: | 1-(3,4-Dihydroxy-benzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol | CHEMBL19844 | D,L-laudanosoline (JW9-3) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19NO4 |
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| Mol. Mass. | 301.3371 |
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| SMILES | CN1CCc2cc(O)c(O)cc2C1Cc1ccc(O)c(O)c1 |
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| Structure | 
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