| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase acidic protein [1-204,T86I,G186S] |
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| Ligand | BDBM105194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fragment Screening |
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| IC50 | 2.50e+5±n/a nM |
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| Citation |  Bauman, JD; Patel, D; Baker, SF; Vijayan, RS; Xiang, A; Parhi, AK; Martínez-Sobrido, L; Martínez-Sobrido, EJ; Das, K; Arnold, E Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. ACS Chem Biol8:2501-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase acidic protein [1-204,T86I,G186S] |
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| Name: | Polymerase acidic protein [1-204,T86I,G186S] |
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| Synonyms: | 2009 H1N1 Influenza polymerase acidic protein N-terminal endonuclease domain | H1N1 Endonuclease | PA | PA_I80A6 |
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| Type: | Protein |
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| Mol. Mass.: | 28455.35 |
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| Organism: | 2009 H1N1 Influenza |
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| Description: | P13166[1-204,T86I,G186S] |
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| Residue: | 241 |
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| Sequence: | MAHHHHHHSRAWRHPQFGGHHHHHHALEVLFQGPLGSMEDFVRQCFNPMIVELAEKAMKE
YGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRD
RIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKT
HIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEETVEE
R
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| BDBM105194 |
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| n/a |
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| Name | BDBM105194 |
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| Synonyms: | methyl 4-(methylsulfanyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N2O3S |
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| Mol. Mass. | 276.311 |
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| SMILES | COC(=O)c1c(SC)nc([nH]c1=O)-c1ccccc1 |
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| Structure | 
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