Reaction Details |
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Target | Polymerase acidic protein [1-204,T86I,G186S] |
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Ligand | BDBM105198 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fragment Screening |
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IC50 | 1.6e+4±n/a nM |
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Citation | Bauman, JD; Patel, D; Baker, SF; Vijayan, RS; Xiang, A; Parhi, AK; Martínez-Sobrido, L; Martínez-Sobrido, EJ; Das, K; Arnold, E Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. ACS Chem Biol8:2501-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polymerase acidic protein [1-204,T86I,G186S] |
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Name: | Polymerase acidic protein [1-204,T86I,G186S] |
Synonyms: | 2009 H1N1 Influenza polymerase acidic protein N-terminal endonuclease domain | H1N1 Endonuclease | PA | PA_I80A6 |
Type: | Protein |
Mol. Mass.: | 28455.35 |
Organism: | 2009 H1N1 Influenza |
Description: | P13166[1-204,T86I,G186S] |
Residue: | 241 |
Sequence: | MAHHHHHHSRAWRHPQFGGHHHHHHALEVLFQGPLGSMEDFVRQCFNPMIVELAEKAMKE
YGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRD
RIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKT
HIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEETVEE
R
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BDBM105198 |
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n/a |
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Name | BDBM105198 |
Synonyms: | 5‐bromo‐3‐hydroxy‐1,2‐dihydropyridin‐2‐one (Compound 2) |
Type | Small organic molecule |
Emp. Form. | C5H4BrNO2 |
Mol. Mass. | 189.995 |
SMILES | Oc1cc(Br)c[nH]c1=O |
Structure |
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