| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM105207 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In vitro Binding Affinity Assay |
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| pH | 7.7±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 24.0±2.6 nM |
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| Comments | extracted |
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| Citation |  Gabrielsen, M; Wolosewicz, K; Zawadzka, A; Kossakowski, J; Nowak, G; Wolak, M; Stachowicz, K; Siwek, A; Ravna, AW; Kufareva, I; Kozerski, L; Bednarek, E; Sitkowski, J; Bocian, W; Abagyan, R; Bojarski, AJ; Sylte, I; Chilmonczyk, Z Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors. Chem Biol Drug Des81:695-706 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70168.43 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P31652 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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| BDBM105207 |
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| n/a |
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| Name | BDBM105207 |
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| Synonyms: | 2-(4-Butyl-piperazin-1-yl)-6-nitroquinoline (4) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22N4O2 |
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| Mol. Mass. | 314.3822 |
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| SMILES | CCCCN1CCN(CC1)c1ccc2cc(ccc2n1)[N+]([O-])=O |
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| Structure | 
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