| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Ligand | BDBM105289 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinase Assay |
|---|
| IC50 | 3±0.0 nM |
|---|
| Citation |  Engelhardt, H; Kofink, C; McConnell, D Chemical compounds US Patent US8575203 Publication Date 11/5/2013 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Name: | 3-phosphoinositide-dependent protein kinase 1 |
|---|
| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 63157.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15530 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
EVWRQRYQSHPDAAVQ
|
|
|
|---|
| BDBM105289 |
|---|
| n/a |
|---|
| Name | BDBM105289 |
|---|
| Synonyms: | US8575203, I-56 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H29F2N7O3 |
|---|
| Mol. Mass. | 585.6039 |
|---|
| SMILES | Fc1ccc(Cn2cncc(C(=O)NCC#Cc3ccc4ncc(NC5CCN(CC5)C5COC5)nc4c3)c2=O)cc1F |
|---|
| Structure | 
|
|---|
Search and Browse
