Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target3-phosphoinositide-dependent protein kinase 1
LigandBDBM105295
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 2±0.0 nM
Citation Engelhardt, HKofink, CMcConnell, D Chemical compounds US Patent US8575203 Publication Date 11/5/2013
More Info.:Get all data from this article,  Assay Method
 
3-phosphoinositide-dependent protein kinase 1
Name:3-phosphoinositide-dependent protein kinase 1
Synonyms:3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1
Type:Enzyme
Mol. Mass.:63157.65
Organism:Homo sapiens (Human)
Description:O15530
Residue:556
Sequence:
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
EVWRQRYQSHPDAAVQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM105295
n/a
NameBDBM105295
Synonyms:US8575203, I-62
TypeSmall organic molecule
Emp. Form.C37H40F2N8O2
Mol. Mass.666.7627
SMILESFc1ccc(Cn2nccc(C(=O)NCC#Cc3ccc4ncc(N[C@H]5CC[C@@H](CC5)N5CCN(CC6CC6)CC5)nc4c3)c2=O)cc1F |r,wU:25.24,wD:28.31,(9.34,-1.54,;8,-.77,;8,.77,;6.67,1.54,;5.33,.77,;4,1.54,;4,3.08,;5.33,3.85,;5.33,5.39,;4,6.16,;2.67,5.39,;1.33,6.16,;1.33,7.7,;,5.39,;-1.33,6.16,;-2.67,5.39,;-4,4.62,;-5.33,3.85,;-6.67,4.62,;-8,3.85,;-8,2.31,;-9.34,1.54,;-9.34,,;-8,-.77,;-8,-2.31,;-6.67,-3.08,;-5.33,-2.31,;-4,-3.08,;-4,-4.62,;-5.33,-5.39,;-6.67,-4.62,;-2.67,-5.39,;-2.67,-6.93,;-1.33,-7.7,;,-6.93,;1.33,-7.7,;2.67,-6.93,;4.21,-6.93,;3.44,-5.6,;,-5.39,;-1.33,-4.62,;-6.67,,;-6.67,1.54,;-5.33,2.31,;2.67,3.85,;1.33,3.08,;5.33,-.77,;6.67,-1.54,;6.67,-3.08,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: