Reaction Details | |||
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Target | 3-phosphoinositide-dependent protein kinase 1 | ||
Ligand | BDBM105295 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
IC50 | 2±0.0 nM | ||
Citation | Engelhardt, H; Kofink, C; McConnell, D Chemical compounds US Patent US8575203 Publication Date 11/5/2013 | ||
More Info.: | Get all data from this article, Assay Method | ||
3-phosphoinositide-dependent protein kinase 1 | |||
Name: | 3-phosphoinositide-dependent protein kinase 1 | ||
Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 63157.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O15530 | ||
Residue: | 556 | ||
Sequence: |
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BDBM105295 | |||
n/a | |||
Name | BDBM105295 | ||
Synonyms: | US8575203, I-62 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H40F2N8O2 | ||
Mol. Mass. | 666.7627 | ||
SMILES | Fc1ccc(Cn2nccc(C(=O)NCC#Cc3ccc4ncc(N[C@H]5CC[C@@H](CC5)N5CCN(CC6CC6)CC5)nc4c3)c2=O)cc1F |r,wU:25.24,wD:28.31,(9.34,-1.54,;8,-.77,;8,.77,;6.67,1.54,;5.33,.77,;4,1.54,;4,3.08,;5.33,3.85,;5.33,5.39,;4,6.16,;2.67,5.39,;1.33,6.16,;1.33,7.7,;,5.39,;-1.33,6.16,;-2.67,5.39,;-4,4.62,;-5.33,3.85,;-6.67,4.62,;-8,3.85,;-8,2.31,;-9.34,1.54,;-9.34,,;-8,-.77,;-8,-2.31,;-6.67,-3.08,;-5.33,-2.31,;-4,-3.08,;-4,-4.62,;-5.33,-5.39,;-6.67,-4.62,;-2.67,-5.39,;-2.67,-6.93,;-1.33,-7.7,;,-6.93,;1.33,-7.7,;2.67,-6.93,;4.21,-6.93,;3.44,-5.6,;,-5.39,;-1.33,-4.62,;-6.67,,;-6.67,1.54,;-5.33,2.31,;2.67,3.85,;1.33,3.08,;5.33,-.77,;6.67,-1.54,;6.67,-3.08,)| | ||
Structure |