| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Ligand | BDBM106775 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IC50 Assay |
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| pH | 8±0 |
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| Temperature | 296.15±0 K |
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| IC50 | 1.3e+4±n/a nM |
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| Citation |  Mascayano, C; Espinosa, V; Sepúlveda-Boza, S; Sepúlveda-Boza, EK; Perry, S In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases. Chem Biol Drug Des82:317-25 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
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| Type: | Protein |
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| Mol. Mass.: | 75689.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18054 |
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| Residue: | 663 |
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| Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
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| BDBM106775 |
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| n/a |
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| Name | BDBM106775 |
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| Synonyms: | 6,7‐dihydroxy‐3‐(4‐nitrophenyl)‐4H‐chromen‐4‐one | 6,7-Dihydroxy-4′-nitroisoflavone (1b) | IR-6 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9NO6 |
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| Mol. Mass. | 299.2351 |
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| SMILES | Oc1cc2occ(-c3ccc(cc3)[N+]([O-])=O)c(=O)c2cc1O |
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| Structure | 
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