| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM106776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IC50 Assay |
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| pH | 7.5±0 |
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| Temperature | 296.15±0 K |
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| IC50 | 5.9e+2±n/a nM |
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| Citation |  Mascayano, C; Espinosa, V; Sepúlveda-Boza, S; Sepúlveda-Boza, EK; Perry, S In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases. Chem Biol Drug Des82:317-25 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
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| Type: | Protein |
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| Mol. Mass.: | 74804.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 662 |
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| Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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| BDBM106776 |
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| n/a |
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| Name | BDBM106776 |
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| Synonyms: | 3‐(3‐chlorophenyl)‐6,7‐dihydroxy‐4H‐chromen‐4‐one | 6,7-Dihydroxy-3′-chloro-isoflavone (1c) | IR-8 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9ClO4 |
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| Mol. Mass. | 288.683 |
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| SMILES | Oc1cc2occ(-c3cccc(Cl)c3)c(=O)c2cc1O |
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| Structure | 
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