| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase |
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| Ligand | BDBM50385302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Ki | 4e+1±n/a nM |
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| IC50 | 2.1e+3±n/a nM |
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| Citation |  Holmgren, A; Lu, J; Vlamis-Gardikas, A; Zhao, R; Kandasamy, K; Engman, L; Engstrand, L; Hoffner, S Bacterial thioredoxin reductase inhibitors and methods for use thereof US Patent US8592468 Publication Date 11/26/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Thioredoxin reductase |
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| Name: | Thioredoxin reductase |
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| Synonyms: | TRXB_ECOLI | Thioredoxin reductase (TrxR) | trxB |
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| Type: | Protein |
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| Mol. Mass.: | 34615.59 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | P0A9P4 |
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| Residue: | 321 |
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| Sequence: | MGTTKHSKLLILGSGPAGYTAAVYAARANLQPVLITGMEKGGQLTTTTEVENWPGDPNDL
TGPLLMERMHEHATKFETEIIFDHINKVDLQNRPFRLNGDNGEYTCDALIIATGASARYL
GLPSEEAFKGRGVSACATCDGFFYRNQKVAVIGGGNTAVEEALYLSNIASEVHLIHRRDG
FRAEKILIKRLMDKVENGNIILHTNRTLEEVTGDQMGVTGVRLRDTQNSDNIESLDVAGL
FVAIGHSPNTAIFEGQLELENGYIKVQSGIHGNATQTSIPGVFAAGDVMDHIYRQAITSA
GTGCMAALDAERYLDGLADAK
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| BDBM50385302 |
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| n/a |
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| Name | BDBM50385302 |
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| Synonyms: | CHEMBL2035461 | US8592468, EbSe15 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N2O2Se2 |
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| Mol. Mass. | 436.23 |
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| SMILES | O=c1n(CCCn2[se]c3ccccc3c2=O)[se]c2ccccc12 |
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| Structure | 
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