Ki Summary

Reaction Details

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Target

Acetyl-coenzyme A transporter 1

Ligand

BDBM107436

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

7.4±0

IC50

1.7±0.0 nM

Citation

Maekawa, T; Igawa, H Fused ring compound and use thereof US Patent US8592431 Publication Date 11/26/2013

More Info.:

Get all data from this article, Solution Info, Assay Method

Acetyl-coenzyme A transporter 1

Name:

Acetyl-coenzyme A transporter 1

Synonyms:

ACATN | ACATN_HUMAN | AT1 | Acetyl-coenzyme A transporter 1 (AT1) | SLC33A1

Type:

Enzyme

Mol. Mass.:

60911.27

Organism:

Homo sapiens (Human)

Description:

O00400

Residue:

549

Sequence:

MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD
FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS
LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT
VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL
LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP
LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL
HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS
SSWKCKRNN

BDBM107436

n/a

Name

BDBM107436

Synonyms:

US8592431, 355

Type

Small organic molecule

Emp. Form.

C35H41FN6O5

Mol. Mass.

644.7356

SMILES

CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OC(CC)C(C)(C)O)c2ncnn12 |r,wU:28.30,wD:31.37,(-6.67,1.78,;-5.33,2.55,;-4,1.78,;-2.67,2.55,;-1.33,1.78,;-1.33,.24,;-2.67,-.53,;-4,.24,;-5.33,-.53,;-5.33,-2.07,;-4,-2.84,;-2.67,-2.07,;-1.33,-2.84,;-6.67,-2.84,;-8,-2.07,;-9.34,-2.84,;-9.34,-4.38,;-8,-5.15,;-6.67,-4.38,;-5.33,-5.15,;-5.33,-6.69,;-3.87,-7.17,;-3.1,-8.5,;-2.96,-5.92,;-3.87,-4.68,;,2.55,;1.33,1.78,;,4.09,;1.33,4.86,;1.33,6.4,;2.67,7.17,;4,6.4,;4,4.86,;2.67,4.09,;5.33,7.17,;6.67,6.4,;6.67,4.86,;5.33,4.09,;8,7.17,;7.23,8.5,;8.77,8.5,;9.34,6.4,;-1.33,4.86,;-1.65,6.36,;-3.19,6.53,;-3.81,5.12,;-2.67,4.09,)|

Structure