Ki Summary

Reaction Details

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Target

Acetyl-coenzyme A transporter 1

Ligand

BDBM107445

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

7.4±0

IC50

1.2±0.0 nM

Citation

Maekawa, T; Igawa, H Fused ring compound and use thereof US Patent US8592431 Publication Date 11/26/2013

More Info.:

Get all data from this article, Solution Info, Assay Method

Acetyl-coenzyme A transporter 1

Name:

Acetyl-coenzyme A transporter 1

Synonyms:

ACATN | ACATN_HUMAN | AT1 | Acetyl-coenzyme A transporter 1 (AT1) | SLC33A1

Type:

Enzyme

Mol. Mass.:

60911.27

Organism:

Homo sapiens (Human)

Description:

O00400

Residue:

549

Sequence:

MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGD
FLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFS
LKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALT
VAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADF
CNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKL
LFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILP
LIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYAL
HQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECV
GASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGS
SSWKCKRNN

BDBM107445

n/a

Name

BDBM107445

Synonyms:

US8592431, 376

Type

Small organic molecule

Emp. Form.

C32H36N6O4

Mol. Mass.

568.666

SMILES

CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)C(C)(C)O)c2ncnn12 |(-5.33,1.78,;-4,2.55,;-2.67,1.78,;-1.33,2.55,;,1.78,;,.24,;-1.33,-.53,;-2.67,.24,;-4,-.53,;-4,-2.07,;-2.67,-2.84,;-1.33,-2.07,;-5.33,-2.84,;-6.67,-2.07,;-8,-2.84,;-8,-4.38,;-6.67,-5.15,;-5.33,-4.38,;-4,-5.15,;-4,-6.69,;-2.54,-7.17,;-1.77,-8.5,;-1.63,-5.92,;-2.54,-4.68,;1.33,2.55,;2.67,1.78,;1.33,4.09,;2.67,4.86,;4,4.09,;5.33,4.86,;5.33,6.4,;4,7.17,;2.67,6.4,;6.67,7.17,;5.9,8.5,;7.44,8.5,;8,6.4,;,4.86,;-.32,6.36,;-1.85,6.53,;-2.48,5.12,;-1.33,4.09,)|

Structure