Reaction Details |
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Target | Cyclin-dependent kinase 4 |
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Ligand | BDBM107758 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Activity Assay |
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pH | 7.5±0 |
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IC50 | 195±n/a nM |
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Citation | Howard, S; Mortenson, PN; Hiscock, SD; Woolford, AJ; Woodhead, AJ; Chessari, G; O'Reilly, M; Congreve, MS; Dagostin, C; Cho, YS; Yang, F; Chen, CH; Brain, CT; Lagu, B; Wang, Y; Kim, S; Giraldes, J; Luzzio, MJ; Perez, LB Imidazole derivatives and their use as modulators of cyclin dependent kinases US Patent US8598217 Publication Date 12/3/2013 |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cyclin-dependent kinase 4 |
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Name: | Cyclin-dependent kinase 4 |
Synonyms: | Cyclin-dependent kinase 4 (CDK4) |
Type: | Enzyme |
Mol. Mass.: | 21063.86 |
Organism: | Oryctolagus cuniculus (Rabbit) |
Description: | Q0GMK6 |
Residue: | 189 |
Sequence: | HFVALKSVRVPNGGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKV
TLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMCQFLRGLDFLHANCIVHRDLKPENILVT
SSGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSAGCIFAEMFR
RKPLFCGNS
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BDBM107758 |
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n/a |
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Name | BDBM107758 |
Synonyms: | US8598217, 167 |
Type | Small organic molecule |
Emp. Form. | C24H28N8O |
Mol. Mass. | 444.5321 |
SMILES | CN(C)C1CCN(CC1)c1ccc2[nH]c(nc2n1)C(=O)c1ccnc(c1)-c1c(C)n[nH]c1C |
Structure |
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