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TargetCyclin-dependent kinase 4
LigandBDBM107758
Substrate/Competitorn/a
Meas. Tech.Enzymatic Activity Assay
pH7.5±0
IC50 195±n/a nM
Citation Howard, SMortenson, PNHiscock, SDWoolford, AJWoodhead, AJChessari, GO'Reilly, MCongreve, MSDagostin, CCho, YSYang, FChen, CHBrain, CTLagu, BWang, YKim, SGiraldes, JLuzzio, MJPerez, LB Imidazole derivatives and their use as modulators of cyclin dependent kinases US Patent US8598217 Publication Date 12/3/2013
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Cyclin-dependent kinase 4
Name:Cyclin-dependent kinase 4
Synonyms:Cyclin-dependent kinase 4 (CDK4)
Type:Enzyme
Mol. Mass.:21063.86
Organism:Oryctolagus cuniculus (Rabbit)
Description:Q0GMK6
Residue:189
Sequence:
HFVALKSVRVPNGGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKV
TLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMCQFLRGLDFLHANCIVHRDLKPENILVT
SSGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSAGCIFAEMFR
RKPLFCGNS
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  Blast E-value cutoff:
BDBM107758
n/a
NameBDBM107758
Synonyms:US8598217, 167
TypeSmall organic molecule
Emp. Form.C24H28N8O
Mol. Mass.444.5321
SMILESCN(C)C1CCN(CC1)c1ccc2[nH]c(nc2n1)C(=O)c1ccnc(c1)-c1c(C)n[nH]c1C
Structure
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