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TargetGlucosylceramidase
LigandBDBM108225
Substrate/Competitorn/a
Meas. Tech.GCase IC50 Assay
pH7±0
IC50 11.5±0.0 nM
Citation Li ZLi TDai SXie XMa XZhao WZhang WLi JWang PG New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease. Chembiochem 14:1239-47 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucosylceramidase
Name:Glucosylceramidase
Synonyms:Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GCase | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (Human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM108225
n/a
NameBDBM108225
Synonyms:2,2-dimethyl-N-phenyl-5-[6,7,8-trihydroxy-5- (hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyridin-2- yl]pentanamide (Compound 11)
TypeSmall organic molecule
Emp. Form.C21H29N3O5
Mol. Mass.403.4721
SMILESCC(C)(CCCc1cn2C(CO)C(O)C(O)C(O)c2n1)C(=O)Nc1ccccc1
Structure
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