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Target1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase))
LigandBDBM108227
Substrate/Competitorn/a
Meas. Tech.DXP Synthase Inhibition Assay
pH8±n/a
Temperature310.15±n/a K
IC50 8.44e+5± 1.70e+5 nM
Commentsextracted
Citation Morris FVierling RBoucher LBosch JFreel Meyers CL DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem 14:1309-15 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase))
Name:1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase))
Synonyms:n/a
Type:Protein
Mol. Mass.:67617.17
Organism:Escherichia coli K-12 (Enterobacteria)
Description:n/a
Residue:620
Sequence:
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
RAELGLDAAGMEAKIKAWLA
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BDBM108227
n/a
NameBDBM108227
Synonyms:NDMA (Substrate 4)
TypeSmall organic molecule
Emp. Form.C8H10N2O
Mol. Mass.150.1778
SMILESCN(C)c1ccc(cc1)N=O
Structure
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