Ki Summary

Reaction Details

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Target

1-deoxy-D-xylulose-5-phosphate synthase

Ligand

BDBM108228

Substrate/Competitor

n/a

Meas. Tech.

DXP Synthase Inhibition Assay

8±n/a

Temperature

310.15±n/a K

4.22e+5± 8.0e+4 nM

IC50

1.065e+6± 1.90e+5 nM

Comments

extracted

Citation

Morris, F; Vierling, R; Boucher, L; Bosch, J; Freel Meyers, CL DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem14:1309-15 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

1-deoxy-D-xylulose-5-phosphate synthase

Name:

1-deoxy-D-xylulose-5-phosphate synthase

Synonyms:

1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase)) | DXS_ECOLI | dxs | yajP

Type:

Protein

Mol. Mass.:

67617.17

Organism:

Escherichia coli K-12 (Enterobacteria)

Description:

n/a

Residue:

620

Sequence:

MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
RAELGLDAAGMEAKIKAWLA

BDBM108228

n/a

Name

BDBM108228

Synonyms:

1‐nitroso‐2‐naphthol (Substrate 5)

Type

Small organic molecule

Emp. Form.

C10H7NO2

Mol. Mass.

173.1681

SMILES

Oc1ccc2ccccc2c1N=O

Structure