| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Ligand | BDBM108231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DXP Synthase Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | >2.000e+6±n/a nM |
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| Comments | extracted |
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| Citation |  Morris, F; Vierling, R; Boucher, L; Bosch, J; Freel Meyers, CL DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem14:1309-15 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose-5-phosphate synthase |
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| Name: | 1-deoxy-D-xylulose-5-phosphate synthase |
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| Synonyms: | 1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase)) | DXS_ECOLI | dxs | yajP |
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| Type: | Protein |
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| Mol. Mass.: | 67617.17 |
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| Organism: | Escherichia coli K-12 (Enterobacteria) |
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| Description: | n/a |
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| Residue: | 620 |
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| Sequence: | MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILND
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
RAELGLDAAGMEAKIKAWLA
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| BDBM108231 |
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| n/a |
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| Name | BDBM108231 |
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| Synonyms: | 7‐methoxy‐1‐nitrosonaphthalen‐2‐ol (Substrate 8) |
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| Type | Small organic molecule |
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| Emp. Form. | C11H9NO3 |
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| Mol. Mass. | 203.1941 |
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| SMILES | COc1ccc2ccc(O)c(N=O)c2c1 |
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| Structure | 
|
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