Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM281745 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Human Recombinant Btk Enzyme Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.077±n/a nM | ||
Comments | extracted | ||
Citation | Watterson, SH; Tebben, AJ; Ahmad, S Carbazole and tetrahydrocarbazole compounds useful as inhibitors of BTK US Patent US10023534 Publication Date 7/17/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
| ||
BDBM281745 | |||
n/a | |||
Name | BDBM281745 | ||
Synonyms: | US10023534, Example 3 | US10023534, Example 8 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H18FN3O3 | ||
Mol. Mass. | 415.4164 | ||
SMILES | NC(=O)c1cc(F)c(-c2cccc3N(CCOc23)C(=O)C=C)c2c3ccccc3[nH]c12 |(2.26,6.93,;.93,6.16,;-.4,6.93,;.93,4.62,;2.26,3.85,;2.26,2.31,;3.6,1.54,;.93,1.54,;.93,,;-.4,-.77,;-.4,-2.31,;.93,-3.08,;2.26,-2.31,;3.6,-3.08,;4.93,-2.31,;4.93,-.77,;3.6,,;2.26,-.77,;3.6,-4.62,;2.26,-5.39,;4.93,-5.39,;4.93,-6.93,;-.4,2.31,;-1.87,1.83,;-2.49,.43,;-4.03,.27,;-4.93,1.51,;-4.3,2.92,;-2.77,3.08,;-1.87,4.33,;-.4,3.85,)| | ||
Structure |