| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-alpha serine/threonine-protein kinase |
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| Ligand | BDBM108428 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alpha Screen Assay |
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| pH | 8±0 |
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| Temperature | 298.15±0 K |
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| IC50 | 1.63±n/a nM |
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| Citation |  Ashwell, MA; Brassard, C; Filikov, A; Hill, J; Koerner, S; Lapierre, J; Liu, Y; Namdev, N; Nicewonger, R; Palma, R; Tandon, M; Vensel, D; Matsuda, A; Iimura, S; Yoshida, K; Yamazaki, T; Kitamura, T; Isoyama, T Substituted imidazopyridinyl-aminopyridine compounds US Patent US8609688 Publication Date 12/17/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| RAC-alpha serine/threonine-protein kinase |
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| Name: | RAC-alpha serine/threonine-protein kinase |
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| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55681.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31749 |
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| Residue: | 480 |
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| Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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| BDBM108428 |
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| n/a |
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| Name | BDBM108428 |
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| Synonyms: | US8609688, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H31N7O2 |
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| Mol. Mass. | 533.6235 |
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| SMILES | CC(C)(O)C(=O)Nc1cccc(c1)-c1ccc2nc(-c3cccnc3N)n(-c3ccc(cc3)C3(N)CCC3)c2n1 |
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| Structure | 
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