| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A/Targeting protein for Xklp2 [1-43] |
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| Ligand | BDBM109207 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dissociation Kinetics Assay |
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| Temperature | 303.15±n/a K |
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| Kd | 4.34±0.54 nM |
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| Comments | extracted |
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| Citation |  Lavogina, D; Enkvist, E; Viht, K; Uri, A Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689. Chembiochem15:443-50 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Aurora kinase A/Targeting protein for Xklp2 [1-43] |
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| Name: | Aurora kinase A/Targeting protein for Xklp2 [1-43] |
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| Synonyms: | Aurora A/TPX2 (1-43) |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| Component 2 |
| Name: | Targeting protein for Xklp2 [1-43] |
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| Synonyms: | C20orf1 | C20orf2 | DIL2 | HCA519 | Microtubule-associated | TPX2 | TPX2 (aa 1-43) | TPX2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 4917.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9ULW0[1-43] |
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| Residue: | 43 |
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| Sequence: | MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLEN
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| BDBM109207 |
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| n/a |
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| Name | BDBM109207 |
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| Synonyms: | Compound II: Ac-D-Arg6-D-Lys(PromoFluor 647)-D-Lys(MLN8237*)-NH2 |
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| Type | Small organic molecule |
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| Emp. Form. | C109H160ClFN35O19S2 |
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| Mol. Mass. | 2383.238 |
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| SMILES | [#6]-[#6]-[#7]-1\[#6](=[#6]\[#6]=[#6]\[#6]=[#6]\[#6]2=[#7+](-[#6]-[#6])-c3ccc(cc3C2([#6])[#6])S([#8-])(=O)=O)C([#6])([#6]-[#6]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7+]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7+])-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7+])-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7+])-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7+])-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7+])-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6](-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-c2ccc(-[#7]-c3ncc4-[#6]-[#7]=[#6](-c5cc(Cl)ccc5-c4n3)-c3c(F)cccc3-[#8]-[#6])cc2-[#8]-[#6])-[#6](-[#7])=O)c2cc(ccc-12)S([#8-])(=O)=O |c:9,132| |
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| Structure | 
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