Ki Summary

Reaction Details

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Target

Carboxypeptidase B2

Ligand

BDBM109254

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Inhibition Assay

IC50

7.0±n/a nM

Citation

Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent US8609710 Publication Date 12/17/2013

More Info.:

Get all data from this article, Assay Method

Carboxypeptidase B2

Name:

Carboxypeptidase B2

Synonyms:

Type:

Enzyme

Mol. Mass.:

48432.74

Organism:

Homo sapiens (Human)

Description:

Q96IY4

Residue:

423

Sequence:

MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV

BDBM109254

n/a

Name

BDBM109254

Synonyms:

US8609710, 25

Type

Small organic molecule

Emp. Form.

C16H27N3O3

Mol. Mass.

309.4039

SMILES

C[C@H](CN)OC(Cc1cn(cn1)[C@H]1CC[C@H](C)CC1)C(O)=O |r,wU:12.12,1.0,wD:15.16,(4.54,-1.29,;3.21,-.52,;3.21,1.02,;4.54,1.79,;1.87,-1.29,;1.87,-2.83,;.54,-3.6,;-.79,-2.83,;-.79,-1.29,;-2.26,-.81,;-3.16,-2.06,;-2.26,-3.3,;-2.66,.68,;-4.14,1.07,;-4.54,2.56,;-3.45,3.65,;-3.85,5.14,;-1.97,3.25,;-1.57,1.76,;3.21,-3.6,;3.21,-5.14,;4.54,-2.83,)|

Structure