Reaction Details |
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Target | Transmembrane prolyl 4-hydroxylase |
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Ligand | BDBM109268 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 2.6e+2±n/a nM |
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Citation | Thede, K; Flamme, I; Oehme, F; Ergüden, J; Stoll, F; Wild, H; Kolkhof, P; Beck, H; Jeske, M Substituted dipyridyl-dihydropyrazolones and use thereof US Patent US8609698 Publication Date 12/17/2013 |
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More Info.: | Get all data from this article, Assay Method |
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Transmembrane prolyl 4-hydroxylase |
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Name: | Transmembrane prolyl 4-hydroxylase |
Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 56654.25 |
Organism: | Homo sapiens (Human) |
Description: | Q9NXG6 |
Residue: | 502 |
Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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BDBM109268 |
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n/a |
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Name | BDBM109268 |
Synonyms: | US8609698, 10 |
Type | Small organic molecule |
Emp. Form. | C14H9BrN4O3 |
Mol. Mass. | 361.15 |
SMILES | OC(=O)c1ccc(nc1)-n1[nH]cc(-c2cncc(Br)c2)c1=O |
Structure |
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