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Targetsodium-dependent glucose cotransporter 2 (SGLT2)
LigandBDBM109274
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 9.53±0.0 nM
Citation Yang FTang PCDong QTu WFan JGuan DShen GWang YYuan JZhang L C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof US Patent  US8609622 Publication Date 12/17/2013
More Info.:Get all data from this article,  Assay Method
 
sodium-dependent glucose cotransporter 2 (SGLT2)
Name:sodium-dependent glucose cotransporter 2 (SGLT2)
Synonyms:Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2
Type:Protein
Mol. Mass.:73014.31
Organism:Mus musculus (Mouse)
Description:Q923I7
Residue:670
Sequence:
MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTV
SKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKEL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTL
GISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQS
PAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMT
VAVFLWGFYA
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  Blast E-value cutoff:
BDBM109274
n/a
NameBDBM109274
Synonyms:US8609622, 1
TypeSmall organic molecule
Emp. Form.C25H29ClO8
Mol. Mass.492.946
SMILESOC[C@]12CO[C@](O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc(OCCOC3CC3)cc2)c1 |r|
Structure
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