Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Targetsodium-dependent glucose cotransporter 1 (SGLT1)
LigandBDBM109279
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 14260±0.0 nM
Citation Yang FTang PCDong QTu WFan JGuan DShen GWang YYuan JZhang L C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof US Patent  US8609622 Publication Date 12/17/2013
More Info.:Get all data from this article,  Assay Method
 
sodium-dependent glucose cotransporter 1 (SGLT1)
Name:sodium-dependent glucose cotransporter 1 (SGLT1)
Synonyms:SGLT1 protein | Solute carrier family 5 (Sodium/glucose cotransporter), member 1 | Uncharacterized protein
Type:Protein
Mol. Mass.:73320.01
Organism:Mus musculus (Mouse)
Description:Q9QXI6
Residue:665
Sequence:
MDSSTLSPAVTATDAPIPSYERIRNAADISVIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEWNALVLVVVLGWIFVPIY
IKAGVVTMPEYLRKRFGGKRIQIYLSVLSLLLYIFTKISADIFSGAIFINLALGLDIYLA
IFILLAITALYTITGGLAAVIYTDTLQTAIMLVGSFILTGFAFNEVGGYEAFMDKYMKAI
PTKVSNGNFTAKEECYTPRADSFHIFRDPITGDMPWPGLIFGLAILALWYWCTDQVIVQR
CLSAKNMSHVKAGCTLCGYLKLLPMFLMVMPGMISRILYTEKIACVLPEECQKYCGTPVG
CTNIAYPTLVVELMPNGLRGLMLSVMMASLMSSLTSIFNSASTLFTMDIYTKIRKKASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRV
NEQGAFWGLILGFLIGISRMITEFAYGTGSCMEPSNCPKIICGVHYLYFAIILFVISVIT
ILIISFLTKPIPDVHLYRLCWSLRNSKEERIDLDAGEEEDIPEDSKDTIEIDTEAPQKKK
GCFRRAYDLFCGLDQDKGPKMTKEEEEAMKMKMTDTSEKPLWRTVVNINGIILLAVAVFC
HAYFA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM109279
n/a
NameBDBM109279
Synonyms:US8609622, 7
TypeSmall organic molecule
Emp. Form.C22H22ClF3O7
Mol. Mass.490.854
SMILESOC[C@]12COC(O1)([C@H](O)[C@@H](O)[C@@H]2O)c1ccc(Cl)c(Cc2ccc(OCC(F)(F)F)cc2)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: