| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM23866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | µ-Calpain Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 100.0± 0.9 nM |
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| Comments | extracted |
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| Citation |  Baek, KH; Karki, R; Lee, ES; Na, Y; Kwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem51:24-30 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM23866 |
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| n/a |
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| Name | BDBM23866 |
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| Synonyms: | MDL28170 | Z-Val-Phe-CHO | benzyl N-[(1S)-2-methyl-1-[(1-oxo-3-phenylpropan-2-yl)carbamoyl]propyl]carbamate | calpain inhibitor III | med.21724, Compound 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N2O4 |
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| Mol. Mass. | 382.4528 |
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| SMILES | CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O |
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| Structure | 
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