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TargetCathepsin B
LigandBDBM110196
Substrate/Competitorn/a
Meas. Tech.Cathepsin B Inhibition Assay
pH5.5±n/a
Temperature310.15±n/a K
IC50>1.00e+5±n/a nM
Commentsextracted
Citation Baek, KHKarki, RLee, ESNa, YKwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem51:24-30 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin B
Name:Cathepsin B
Synonyms:APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:Enzyme
Mol. Mass.:37819.69
Organism:Homo sapiens (Human)
Description:gi_63102437
Residue:339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM110196
n/a
NameBDBM110196
Synonyms:1-(3,5-Dihydroxyphenyl)-3-(thiophen-3-yl)propenone (23)
TypeSmall organic molecule
Emp. Form.C13H10O3S
Mol. Mass.246.282
SMILESOc1cc(O)cc(c1)C(=O)\C=C\c1ccsc1
Structure
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