| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Procathepsin L |
|---|
| Ligand | BDBM110185 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Cathepsin L Inhibition Assay |
|---|
| pH | 5.5±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 5.7± 0.02 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Baek, KH; Karki, R; Lee, ES; Na, Y; Kwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem51:24-30 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Procathepsin L |
|---|
| Name: | Procathepsin L |
|---|
| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37557.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Purchased from Calbiochem (San Diego, CA). |
|---|
| Residue: | 333 |
|---|
| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
|
|
|
|---|
| BDBM110185 |
|---|
| n/a |
|---|
| Name | BDBM110185 |
|---|
| Synonyms: | Z-FF-FMK | benzyl N-[1-[(4-fluoro-3-oxo-1-phenylbutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27FN2O4 |
|---|
| Mol. Mass. | 462.5127 |
|---|
| SMILES | FCC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
