Reaction Details |
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Target | Procathepsin L |
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Ligand | BDBM110189 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Cathepsin L Inhibition Assay |
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pH | 5.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 5.301e+4± 178 nM |
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Comments | extracted |
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Citation | Baek, KH; Karki, R; Lee, ES; Na, Y; Kwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem51:24-30 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Procathepsin L |
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Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM110189 |
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n/a |
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Name | BDBM110189 |
Synonyms: | 1-(2,4-Dihydroxyphenyl)-3-(thiophen-2-yl)propenone (9) |
Type | Small organic molecule |
Emp. Form. | C13H10O3S |
Mol. Mass. | 246.282 |
SMILES | Oc1ccc(C(=O)\C=C\c2cccs2)c(O)c1 |
Structure |
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