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TargetProcathepsin L
LigandBDBM110189
Substrate/Competitorn/a
Meas. Tech.Cathepsin L Inhibition Assay
pH5.5±n/a
Temperature310.15±n/a K
IC50 5.301e+4± 178 nM
Commentsextracted
Citation Baek, KHKarki, RLee, ESNa, YKwon, Y Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorg Chem51:24-30 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Procathepsin L
Name:Procathepsin L
Synonyms:CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM110189
n/a
NameBDBM110189
Synonyms:1-(2,4-Dihydroxyphenyl)-3-(thiophen-2-yl)propenone (9)
TypeSmall organic molecule
Emp. Form.C13H10O3S
Mol. Mass.246.282
SMILESOc1ccc(C(=O)\C=C\c2cccs2)c(O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: