| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-973] |
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| Ligand | BDBM110206 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EGFR, MAPK and PDK Inhibitory Acitivity Assay |
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| pH | 7±n/a |
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| IC50 | >3.00e+5±n/a nM |
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| Comments | extracted |
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| Citation |  Chand, K; Prasad, S; Tiwari, RK; Shirazi, AN; Kumar, S; Parang, K; Sharma, SK Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives. Bioorg Chem53:75-82 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-973] |
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| Name: | Epidermal growth factor receptor [1-973] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase erbB-1 |
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| Type: | Protein |
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| Mol. Mass.: | 108055.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-973] |
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| Residue: | 973 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMAR
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| BDBM110206 |
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| n/a |
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| Name | BDBM110206 |
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| Synonyms: | 1-[2-(Dimethylamino)ethyl]-5-(2-hydroxy-4-methoxybenzoyl) pyridin-2(1H)-one (36) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N2O4 |
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| Mol. Mass. | 316.3517 |
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| SMILES | COc1ccc(C(=O)c2ccc(=O)n(CCN(C)C)c2)c(O)c1 |
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| Structure | 
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