Reaction Details |
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Target | Serine/threonine-protein kinase pim-1 |
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Ligand | BDBM110726 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Pim Kinase Binding Activity |
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pH | 7.2±n/a |
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Ki | 0.002±n/a nM |
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Comments | extracted |
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Citation | Hodges, AJ; Matteucci, M; Sharpe, A; Sun, M; Wang, X; Tsui, VH Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent US8614206 Publication Date 12/24/2013 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase pim-1 |
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Name: | Serine/threonine-protein kinase pim-1 |
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
Type: | Protein |
Mol. Mass.: | 35681.82 |
Organism: | Homo sapiens (Human) |
Description: | P11309 |
Residue: | 313 |
Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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BDBM110726 |
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n/a |
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Name | BDBM110726 |
Synonyms: | US8614206, 252 | US8614206, 254 | US8614206, 352 | US8614206, 353 |
Type | Small organic molecule |
Emp. Form. | C22H27F2N7O2S |
Mol. Mass. | 491.557 |
SMILES | COC1(C)CC(N)CCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C |
Structure |
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