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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-type tyrosine-protein kinase FLT3 | ||
| Ligand | BDBM112460 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.6±n/a | ||
| IC50 | 1.3±n/a nM | ||
| Citation |  Chen, X; Dai, K; Duquette, J; Gribble, Jr., MW; Huard, JN; Keegan, KS; Li, Z; Lively, SE; McGee, LR; Ragains, ML; Wang, X; Weidner, MF; Zhang, J Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 US Patent US8623885 Publication Date 1/7/2014 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Receptor-type tyrosine-protein kinase FLT3 | |||
| Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 112888.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36888 | ||
| Residue: | 993 | ||
| Sequence: |
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| BDBM112460 | |||
| n/a | |||
| Name | BDBM112460 | ||
| Synonyms: | US8623885, 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27N7 | ||
| Mol. Mass. | 413.5181 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CNCCc4n3)nc12 |r,wU:4.7,wD:1.0,(4.13,-4.37,;3.73,-2.88,;4.82,-1.79,;4.42,-.3,;2.93,.09,;1.84,-.99,;2.24,-2.48,;2.53,1.58,;3.44,2.83,;4.97,2.99,;5.6,4.4,;4.69,5.64,;3.16,5.48,;2.53,4.07,;1.07,3.6,;-.26,4.37,;-1.6,3.6,;-1.6,2.06,;-2.93,1.29,;-2.93,-.25,;-1.6,-1.02,;-1.6,-2.56,;-2.93,-3.33,;-2.93,-4.87,;-4.26,-5.64,;-5.6,-4.87,;-5.6,-3.33,;-4.26,-2.56,;-4.26,-1.02,;-.26,1.29,;1.07,2.06,)| | ||
| Structure | 
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