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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-type tyrosine-protein kinase FLT3 | ||
| Ligand | BDBM112462 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.6±n/a | ||
| IC50 | 1.8±n/a nM | ||
| Citation |  Chen, X; Dai, K; Duquette, J; Gribble, Jr., MW; Huard, JN; Keegan, KS; Li, Z; Lively, SE; McGee, LR; Ragains, ML; Wang, X; Weidner, MF; Zhang, J Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 US Patent US8623885 Publication Date 1/7/2014 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Receptor-type tyrosine-protein kinase FLT3 | |||
| Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 112888.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36888 | ||
| Residue: | 993 | ||
| Sequence: |
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| BDBM112462 | |||
| n/a | |||
| Name | BDBM112462 | ||
| Synonyms: | US8623885, 3 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H31N7O | ||
| Mol. Mass. | 457.5706 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCO)CCc4n3)nc12 |r,wU:4.7,wD:1.0,(4.13,-3.21,;3.73,-1.73,;4.82,-.64,;4.42,.85,;2.93,1.25,;1.84,.16,;2.24,-1.33,;2.53,2.74,;3.44,3.98,;4.97,4.14,;5.6,5.55,;4.69,6.8,;3.16,6.64,;2.53,5.23,;1.07,4.75,;-.26,5.52,;-1.6,4.75,;-1.6,3.21,;-2.93,2.44,;-2.93,.9,;-1.6,.13,;-1.6,-1.41,;-2.93,-2.18,;-2.93,-3.72,;-4.26,-4.49,;-4.26,-6.03,;-2.93,-6.8,;-1.6,-6.03,;-5.6,-3.72,;-5.6,-2.18,;-4.26,-1.41,;-4.26,.13,;-.26,2.44,;1.07,3.21,)| | ||
| Structure | 
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