Reaction Details | |||
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Target | Receptor-type tyrosine-protein kinase FLT3 | ||
Ligand | BDBM112471 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.6±n/a | ||
IC50 | 2.7±n/a nM | ||
Citation | Chen, X; Dai, K; Duquette, J; Gribble, Jr., MW; Huard, JN; Keegan, KS; Li, Z; Lively, SE; McGee, LR; Ragains, ML; Wang, X; Weidner, MF; Zhang, J Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 US Patent US8623885 Publication Date 1/7/2014 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Receptor-type tyrosine-protein kinase FLT3 | |||
Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 112888.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36888 | ||
Residue: | 993 | ||
Sequence: |
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BDBM112471 | |||
n/a | |||
Name | BDBM112471 | ||
Synonyms: | US8623885, 12 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H31N7O | ||
Mol. Mass. | 457.5706 | ||
SMILES | C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3cc4CN(CCO)CCc4cn3)nc12 |r,wU:4.7,wD:1.0,(3.46,-3.21,;3.06,-1.73,;4.15,-.64,;3.75,.85,;2.27,1.25,;1.18,.16,;1.58,-1.33,;1.87,2.74,;2.77,3.98,;4.3,4.14,;4.93,5.55,;4.03,6.8,;2.49,6.64,;1.87,5.23,;.4,4.75,;-.93,5.52,;-2.26,4.75,;-2.26,3.21,;-3.6,2.44,;-3.6,.9,;-2.26,.13,;-2.26,-1.41,;-.93,-2.18,;-.93,-3.72,;.4,-4.49,;.4,-6.03,;1.74,-6.8,;-2.26,-4.49,;-3.6,-3.72,;-3.6,-2.18,;-4.93,-1.41,;-4.93,.13,;-.93,2.44,;.4,3.21,)| | ||
Structure |