Reaction Details | |||
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Target | Receptor-type tyrosine-protein kinase FLT3 | ||
Ligand | BDBM112477 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.6±n/a | ||
IC50 | 1.6±n/a nM | ||
Citation | Chen, X; Dai, K; Duquette, J; Gribble, Jr., MW; Huard, JN; Keegan, KS; Li, Z; Lively, SE; McGee, LR; Ragains, ML; Wang, X; Weidner, MF; Zhang, J Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 US Patent US8623885 Publication Date 1/7/2014 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Receptor-type tyrosine-protein kinase FLT3 | |||
Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 112888.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36888 | ||
Residue: | 993 | ||
Sequence: |
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BDBM112477 | |||
n/a | |||
Name | BDBM112477 | ||
Synonyms: | US8623885, 18a | ||
Type | Small organic molecule | ||
Emp. Form. | C27H31N7O | ||
Mol. Mass. | 469.5813 | ||
SMILES | C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(C[C@@H](C)c4n3)C(C)=O)nc12 |r,wU:4.7,26.28,wD:1.0,(4.8,5.44,;4.4,6.93,;5.49,8.02,;5.09,9.51,;3.6,9.91,;2.51,8.82,;2.91,7.33,;3.2,11.39,;4.11,12.64,;5.64,12.8,;6.26,14.21,;5.36,15.45,;3.83,15.29,;3.2,13.89,;1.74,13.41,;.4,14.18,;-.93,13.41,;-.93,11.87,;-2.26,11.1,;-2.26,9.56,;-.93,8.79,;-.93,7.25,;-2.26,6.48,;-2.26,4.94,;-3.6,4.17,;-4.93,4.94,;-4.93,6.48,;-6.26,7.25,;-3.6,7.25,;-3.6,8.79,;-3.6,2.63,;-2.26,1.86,;-4.93,1.86,;.4,11.1,;1.74,11.87,)| | ||
Structure |