Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Receptor-type tyrosine-protein kinase FLT3 | ||
Ligand | BDBM112497 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.6±n/a | ||
IC50 | 2.3±n/a nM | ||
Citation | Chen, X; Dai, K; Duquette, J; Gribble, Jr., MW; Huard, JN; Keegan, KS; Li, Z; Lively, SE; McGee, LR; Ragains, ML; Wang, X; Weidner, MF; Zhang, J Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 US Patent US8623885 Publication Date 1/7/2014 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Receptor-type tyrosine-protein kinase FLT3 | |||
Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 112888.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36888 | ||
Residue: | 993 | ||
Sequence: |
| ||
BDBM112497 | |||
n/a | |||
Name | BDBM112497 | ||
Synonyms: | US8623885, 18b | ||
Type | Small orgnaic molecules | ||
Emp. Form. | C27H31N7O | ||
Mol. Mass. | 469.5813 | ||
SMILES | C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(C[C@H](C)c4n3)C(C)=O)nc12 |r,wU:4.7,wD:1.0,26.28,(4.8,-11.87,;4.4,-10.38,;5.49,-9.29,;5.09,-7.81,;3.6,-7.41,;2.51,-8.5,;2.91,-9.98,;3.2,-5.92,;4.11,-4.67,;5.64,-4.51,;6.26,-3.11,;5.36,-1.86,;3.83,-2.02,;3.2,-3.43,;1.74,-3.9,;.4,-3.13,;-.93,-3.9,;-.93,-5.44,;-2.26,-6.21,;-2.26,-7.75,;-.93,-8.52,;-.93,-10.06,;-2.26,-10.83,;-2.26,-12.37,;-3.6,-13.14,;-4.93,-12.37,;-4.93,-10.83,;-6.26,-10.06,;-3.6,-10.06,;-3.6,-8.52,;-3.6,-14.68,;-2.26,-15.45,;-4.93,-15.45,;.4,-6.21,;1.74,-5.44,)| | ||
Structure |