Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 4

Ligand

BDBM112467

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

7.4±n/a

IC50

2.4±n/a nM

Citation

Chen, X; Dai, K; Duquette, J; Gribble, Jr., MW; Huard, JN; Keegan, KS; Li, Z; Lively, SE; McGee, LR; Ragains, ML; Wang, X; Weidner, MF; Zhang, J Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 US Patent US8623885 Publication Date 1/7/2014

More Info.:

Get all data from this article, Solution Info, Assay Method

Cyclin-dependent kinase 4

Name:

Cyclin-dependent kinase 4

Synonyms:

CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3

Type:

Enzyme Subunit

Mol. Mass.:

33731.96

Organism:

Homo sapiens (Human)

Description:

P11802

Residue:

303

Sequence:

MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE

BDBM112467

n/a

Name

BDBM112467

Synonyms:

US8623885, 8

Type

Small organic molecule

Emp. Form.

C27H33N7O2S

Mol. Mass.

519.662

SMILES

C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCS(C)(=O)=O)CCc4n3)nc12 |r,wU:4.7,wD:1.0,(4.13,-3.21,;3.73,-1.73,;4.82,-.64,;4.42,.85,;2.93,1.25,;1.84,.16,;2.24,-1.33,;2.53,2.74,;3.44,3.98,;4.97,4.14,;5.6,5.55,;4.69,6.8,;3.16,6.64,;2.53,5.23,;1.07,4.75,;-.26,5.52,;-1.6,4.75,;-1.6,3.21,;-2.93,2.44,;-2.93,.9,;-1.6,.13,;-1.6,-1.41,;-2.93,-2.18,;-2.93,-3.72,;-4.26,-4.49,;-4.26,-6.03,;-2.93,-6.8,;-1.6,-6.03,;-.26,-6.8,;-2.37,-4.69,;-.83,-4.69,;-5.6,-3.72,;-5.6,-2.18,;-4.26,-1.41,;-4.26,.13,;-.26,2.44,;1.07,3.21,)|

Structure