Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 4

Ligand

BDBM112496

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

7.4±n/a

IC50

3±n/a nM

Citation

Chen, X; Dai, K; Duquette, J; Gribble, Jr., MW; Huard, JN; Keegan, KS; Li, Z; Lively, SE; McGee, LR; Ragains, ML; Wang, X; Weidner, MF; Zhang, J Fused tricyclic dual inhibitors of CDK 4/6 and FLT3 US Patent US8623885 Publication Date 1/7/2014

More Info.:

Get all data from this article, Solution Info, Assay Method

Cyclin-dependent kinase 4

Name:

Cyclin-dependent kinase 4

Synonyms:

CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3

Type:

Enzyme Subunit

Mol. Mass.:

33731.96

Organism:

Homo sapiens (Human)

Description:

P11802

Residue:

303

Sequence:

MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE

BDBM112496

n/a

Name

BDBM112496

Synonyms:

US8623885, 37

Type

Small organic molecule

Emp. Form.

C30H38N8O

Mol. Mass.

526.6757

SMILES

CCN(CC)CC(=O)N1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 |r,wU:26.26,wD:29.30,(-.26,-2.95,;-1.6,-3.72,;-1.6,-5.26,;-.26,-6.03,;-.26,-7.57,;-2.93,-6.03,;-4.26,-5.26,;-5.6,-6.03,;-4.26,-3.72,;-5.6,-2.95,;-5.6,-1.41,;-4.26,-.64,;-4.26,.9,;-2.93,1.67,;-2.93,3.21,;-1.6,3.98,;-1.6,5.52,;-.26,6.29,;1.07,5.52,;2.53,6,;3.16,7.41,;4.69,7.57,;5.6,6.32,;4.97,4.91,;3.44,4.75,;2.53,3.51,;2.93,2.02,;4.42,1.62,;4.82,.13,;3.73,-.96,;4.13,-2.44,;2.24,-.56,;1.84,.93,;1.07,3.98,;-.26,3.21,;-1.6,.9,;-1.6,-.64,;-2.93,-1.41,;-2.93,-2.95,)|

Structure