Reaction Details |
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Target | Gag-Pol polyprotein [484-582,Q491K,I497V,V499I,E519D,G532V,I538V,R541K,D544E,L547P,Q553K,V566A,L573M] |
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Ligand | BDBM112663 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HIV-1 protease inhibition assay |
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pH | 4.7±n/a |
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Temperature | 298.15±n/a K |
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Ki | 0.126±0.014 nM |
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Comments | extracted |
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Citation | Nalam, MN; Ali, A; Reddy, GS; Cao, H; Anjum, SG; Altman, MD; Yilmaz, NK; Tidor, B; Rana, TM; Schiffer, CA Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem Biol20:1116-24 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [484-582,Q491K,I497V,V499I,E519D,G532V,I538V,R541K,D544E,L547P,Q553K,V566A,L573M] |
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Name: | Gag-Pol polyprotein [484-582,Q491K,I497V,V499I,E519D,G532V,I538V,R541K,D544E,L547P,Q553K,V566A,L573M] |
Synonyms: | HIV-1 protease M1 | POL_HV196 | gag-pol |
Type: | Protein |
Mol. Mass.: | 10742.69 |
Organism: | Human immunodeficiency virus |
Description: | HIV-1 protease mutant (L10I, G48V, I54V, L63P, V82A) |
Residue: | 99 |
Sequence: | PQITLWKRPIVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFVKVKQYE
QVPIEICGKKAIGTVLVGPTPANIIGRNMLTQIGCTLNF
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BDBM112663 |
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n/a |
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Name | BDBM112663 |
Synonyms: | (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(N-(2-ethylbutyl)benzo[d]thiazole-6-sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate (11e) |
Type | Small organic molecule |
Emp. Form. | C30H39N3O7S2 |
Mol. Mass. | 617.777 |
SMILES | CCC(CC)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)c1ccc2ncsc2c1 |
Structure |
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