| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [484-582,Q491K,I497V,V499I,E519D,R541K,D544E,L547P,Q553K,A555V,G557S,I568V,L573M,L574M] |
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| Ligand | BDBM112658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HIV-1 protease inhibition assay |
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| pH | 4.7±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 0.041±0.034 nM |
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| Comments | extracted |
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| Citation |  Nalam, MN; Ali, A; Reddy, GS; Cao, H; Anjum, SG; Altman, MD; Yilmaz, NK; Tidor, B; Rana, TM; Schiffer, CA Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem Biol20:1116-24 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [484-582,Q491K,I497V,V499I,E519D,R541K,D544E,L547P,Q553K,A555V,G557S,I568V,L573M,L574M] |
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| Name: | Gag-Pol polyprotein [484-582,Q491K,I497V,V499I,E519D,R541K,D544E,L547P,Q553K,A555V,G557S,I568V,L573M,L574M] |
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| Synonyms: | HIV-1 protease M2 | POL_HV196 | gag-pol |
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| Type: | Protein |
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| Mol. Mass.: | 10804.78 |
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| Organism: | Human immunodeficiency virus |
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| Description: | HIV-1 protease mutant (L10I, L63P, A71V, G73S, I84V, L90M) |
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| Residue: | 99 |
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| Sequence: | PQITLWKRPIVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QVPIEICGKKVISTVLVGPTPVNVIGRNMMTQIGCTLNF
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| BDBM112658 |
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| n/a |
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| Name | BDBM112658 |
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| Synonyms: | (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-3-hydroxy-4-(N-((S)-2-methylbutyl)benzo[d]thiazole-6-sulfonamido)-1-phenylbutan-2-yl)carbamate (10e) |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37N3O7S2 |
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| Mol. Mass. | 603.75 |
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| SMILES | CC[C@H](C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)c1ccc2ncsc2c1 |
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| Structure | 
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