Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 | ||
Ligand | BDBM113163 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Assay | ||
pH | 7.4±n/a | ||
IC50 | 90.6±n/a nM | ||
Comments | extracted | ||
Citation | Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
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BDBM113163 | |||
n/a | |||
Name | BDBM113163 | ||
Synonyms: | US8633206, 81 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H30N6O4S2 | ||
Mol. Mass. | 470.609 | ||
SMILES | CNS(=O)(=O)[C@H]1CCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12 |r,wU:14.14,5.4,wD:17.21,(-9.06,3.9,;-7.57,4.3,;-6.48,3.21,;-6.88,1.73,;-7.97,2.81,;-5,3.61,;-4.09,4.86,;-2.63,4.38,;-2.64,2.84,;-4.09,2.37,;-1.31,2.07,;-1.31,.53,;.02,1.3,;.02,2.84,;1.36,2.07,;2.69,2.84,;4.02,2.07,;4.02,.53,;2.69,-.24,;1.36,.53,;5.36,-.24,;6.69,.53,;5.36,-1.78,;4.02,-2.55,;4.02,-4.09,;5.36,-4.86,;6.69,-4.09,;8.16,-4.56,;9.06,-3.32,;8.16,-2.07,;6.69,-2.55,)| | ||
Structure |