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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM113142 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 1.7±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM113142 | |||
| n/a | |||
| Name | BDBM113142 | ||
| Synonyms: | US8633206, 60 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H31N5O3S | ||
| Mol. Mass. | 421.557 | ||
| SMILES | CO[C@@H]1CCCN(C1)S(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12 |r,wU:12.12,2.1,wD:15.19,(-7.19,6.16,;-5.85,5.39,;-5.85,3.85,;-7.19,3.08,;-7.19,1.54,;-5.85,.77,;-4.52,1.54,;-4.52,3.08,;-3.19,.77,;-3.19,-.77,;-1.85,,;-1.85,1.54,;-.52,.77,;.82,1.54,;2.15,.77,;2.15,-.77,;.82,-1.54,;-.52,-.77,;3.48,-1.54,;4.82,-.77,;3.48,-3.08,;2.15,-3.85,;2.15,-5.39,;3.48,-6.16,;4.82,-5.39,;6.28,-5.87,;7.19,-4.62,;6.28,-3.37,;4.82,-3.85,)| | ||
| Structure | 
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