Reaction Details | |||
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Target | Isoform C of Beta-secretase 1 (BACE-I-457) | ||
Ligand | BDBM113392 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | BACE Assay | ||
IC50 | 3.9±n/a nM | ||
Citation | Cacatian, S; Claremon, DA; Dillard, LW; Fuchs, K; Heine, N; Jia, L; Leftheris, K; McKeever, B; Morales-Ramos, A; Singh, SB; Venkatraman, S; Wu, G; Wu, Z; Xu, Z; Yuan, J; Zheng, Y Inhibitors of beta-secretase US Patent US8633212 Publication Date 1/21/2014 | ||
More Info.: | Get all data from this article, Assay Method | ||
Isoform C of Beta-secretase 1 (BACE-I-457) | |||
Name: | Isoform C of Beta-secretase 1 (BACE-I-457) | ||
Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE) | Beta-secretase 1 (BACE-I-457) | KIAA1149 | ||
Type: | Enzyme | ||
Mol. Mass.: | 51006.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P56817-3 | ||
Residue: | 457 | ||
Sequence: |
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BDBM113392 | |||
n/a | |||
Name | BDBM113392 | ||
Synonyms: | US10336717, Compound 578 | US8633212, 578 | US9212153, 578 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27N3O3 | ||
Mol. Mass. | 405.4895 | ||
SMILES | CO[C@H]1CC[C@@]2(Cc3ccc(Oc4ccccc4)cc3[C@]22N=C(N)N(C)C2=O)CC1 |r,wD:5.5,20.23,2.1,t:24,(7.88,-3.1,;7.11,-1.77,;5.57,-1.77,;4.8,-.43,;3.26,-.43,;2.49,-1.77,;1.59,-3.01,;.12,-2.54,;-1.21,-3.31,;-2.55,-2.54,;-2.55,-1,;-3.88,-.23,;-5.21,-1,;-6.55,-.23,;-7.88,-1,;-7.88,-2.54,;-6.55,-3.31,;-5.21,-2.54,;-1.21,-.23,;.12,-1,;1.59,-.52,;.12,-.04,;.12,1.5,;-1.21,2.27,;1.59,1.97,;2.36,3.31,;2.49,.73,;4.03,.73,;3.26,-3.1,;4.8,-3.1,)| | ||
Structure |