Reaction Details |
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Target | Alpha-galactosidase A |
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Ligand | BDBM113760 |
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Substrate/Competitor | n/a |
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Meas. Tech. | α-Gal A Assay |
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pH | 7±0 |
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IC50 | 2.18e+3± 3.9e+2 nM |
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Citation | Yu, Y; Mena-Barragán, T; Mena-Barragán, K; Johnson, JL; Drury, JE; Lieberman, RL; Nakasone, N; Ninomiya, H; Tsukimura, T; Sakuraba, H; Suzuki, Y; Nanba, E; Mellet, CO; García Fernández, JM; García Fernández, K Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human a-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants. ACS Chem Biol9:1460-9 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-galactosidase A |
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Name: | Alpha-galactosidase A |
Synonyms: | AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase |
Type: | Protein |
Mol. Mass.: | 48760.21 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 429 |
Sequence: | MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL
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BDBM113760 |
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n/a |
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Name | BDBM113760 |
Synonyms: | pF PhIM-DGJ |
Type | Small organic molecule |
Emp. Form. | C13H15FN2O3S |
Mol. Mass. | 298.333 |
SMILES | O[C@H]1CN2C(CS\C2=N\c2ccc(F)cc2)[C@H](O)[C@@H]1O |r| |
Structure |
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