| Reaction Details |
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 | Report a problem with these data |
| Target | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
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| Ligand | BDBM33185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-B3) |
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| IC50 | 122448±n/a nM |
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| Citation |  PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-B3) PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
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| Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
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| Synonyms: | PLCB3 | PLCB3_HUMAN | Phospholipase C, beta 3 (phosphatidylinositol-specific) | Phospholipase C-beta-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138786.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_12586 |
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| Residue: | 1234 |
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| Sequence: | MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS
AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD
EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL
GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH
KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED
TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF
KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE
EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG
DGPLVACASNGHAPGSSGHLSGADSESQEENTQL
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| BDBM33185 |
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| n/a |
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| Name | BDBM33185 |
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| Synonyms: | 4-({(4Z)-1-oxo-4-[(phenylsulfonyl)imino]-1,4-dihydronaphthalen-2-yl}amino)benzoic acid | 4-[(4-besylimino-1-keto-2-naphthyl)amino]benzoic acid | 4-[[(4Z)-4-besylimino-1-keto-2-naphthyl]amino]benzoic acid | 4-[[1-oxidanylidene-4-(phenylsulfonylimino)naphthalen-2-yl]amino]benzoic acid | 4-[[4-(benzenesulfonylimino)-1-oxo-2-naphthalenyl]amino]benzoic acid | 4-[[4-(benzenesulfonylimino)-1-oxonaphthalen-2-yl]amino]benzoic acid | MLS000686314 | SMR000313157 | cid_4053104 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H16N2O5S |
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| Mol. Mass. | 432.449 |
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| SMILES | OC(=O)c1ccc(NC2=CC(=NS(=O)(=O)c3ccccc3)c3ccccc3C2=O)cc1 |w:11.11,t:8| |
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| Structure | 
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