| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Major prion protein |
|---|
| Ligand | BDBM40943 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) |
|---|
| IC50 | 910±n/a nM |
|---|
| Citation |  PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Major prion protein |
|---|
| Name: | Major prion protein |
|---|
| Synonyms: | ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 27671.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_158887 |
|---|
| Residue: | 253 |
|---|
| Sequence: | MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
|
|
|
|---|
| BDBM40943 |
|---|
| n/a |
|---|
| Name | BDBM40943 |
|---|
| Synonyms: | (2-Isopropyl-quinazolin-4-ylsulfanyl)-acetic acid methyl ester | 2-[(2-isopropylquinazolin-4-yl)thio]acetic acid methyl ester | 2-[(2-propan-2-yl-4-quinazolinyl)thio]acetic acid methyl ester | MLS000074241 | SMR000006837 | cid_652110 | methyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetate | methyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16N2O2S |
|---|
| Mol. Mass. | 276.354 |
|---|
| SMILES | COC(=O)CSc1nc(nc2ccccc12)C(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
