Ki Summary

Reaction Details

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Target

Major prion protein

Ligand

BDBM42714

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)

IC50

1691±n/a nM

Citation

PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Major prion protein

Name:

Major prion protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

27671.97

Organism:

Homo sapiens (Human)

Description:

ChEMBL_158887

Residue:

253

Sequence:

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG

BDBM42714

n/a

Name

BDBM42714

Synonyms:

MLS000089894 | N-(3-chlorophenyl)-2-[[5-cyano-6-(2-furanyl)-4-oxo-1H-pyrimidin-2-yl]thio]acetamide | N-(3-chlorophenyl)-2-[[5-cyano-6-(2-furyl)-4-keto-1H-pyrimidin-2-yl]thio]acetamide | N-(3-chlorophenyl)-2-[[5-cyano-6-(furan-2-yl)-4-oxidanylidene-1H-pyrimidin-2-yl]sulfanyl]ethanamide | N-(3-chlorophenyl)-2-[[5-cyano-6-(furan-2-yl)-4-oxo-1H-pyrimidin-2-yl]sulfanyl]acetamide | N-(3-chlorophenyl)-2-{[5-cyano-4-(2-furyl)-6-oxo-1,6-dihydropyrimidin-2-yl]thio}acetamide | SMR000024512 | cid_3240275

Type

Small organic molecule

Emp. Form.

C17H11ClN4O3S

Mol. Mass.

386.812

SMILES

Clc1cccc(NC(=O)CSc2nc(-c3ccco3)c(C#N)c(=O)[nH]2)c1

Structure