| Reaction Details |
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 | Report a problem with these data |
| Target | Major prion protein |
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| Ligand | BDBM95259 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) |
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| IC50 | 142.56±n/a nM |
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| Citation |  PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Major prion protein |
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| Name: | Major prion protein |
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| Synonyms: | ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27671.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_158887 |
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| Residue: | 253 |
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| Sequence: | MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG
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| BDBM95259 |
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| n/a |
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| Name | BDBM95259 |
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| Synonyms: | 3,4-dimethyl-2-(4-methylphenyl)-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-thione | 3,4-dimethyl-2-(4-methylphenyl)-6H-pyrazolo[3,4-d]pyridazine-7-thione | 3,4-dimethyl-2-(p-tolyl)-6H-pyrazolo[3,4-d]pyridazine-7-thione | MLS000325312 | SMR000161327 | cid_1234246 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N4S |
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| Mol. Mass. | 270.353 |
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| SMILES | Cc1n(nc2c1c(C)n[nH]c2=S)-c1ccc(C)cc1 |
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| Structure | 
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