Ki Summary

Reaction Details

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Target

Major prion protein

Ligand

BDBM41062

Substrate/Competitor

n/a

Meas. Tech.

TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)

IC50

1826±n/a nM

Citation

PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay(2014)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Major prion protein

Name:

Major prion protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

27671.97

Organism:

Homo sapiens (Human)

Description:

ChEMBL_158887

Residue:

253

Sequence:

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG

BDBM41062

n/a

Name

BDBM41062

Synonyms:

2-(2-Isopropyl-quinazolin-4-ylsulfanyl)-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-acetamide | 2-[(2-isopropylquinazolin-4-yl)thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide | MLS000556711 | N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-ethanamide | N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetamide | N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-[(2-propan-2-yl-4-quinazolinyl)thio]acetamide | SMR000173439 | cid_1442817

Type

Small organic molecule

Emp. Form.

C16H17N5OS2

Mol. Mass.

359.469

SMILES

CC(C)c1nc(SCC(=O)Nc2nnc(C)s2)c2ccccc2n1

Structure